The first dedicated hematology and medical oncology practice in the Upstate of South Carolina was started in 1976 by Dr. Reginald Brooker. Dr. Brooker was joined by Dr. Gerald King in 1978, and Hematology and Oncology Associates was formed. The group and the area attracted more partners, all of whom possessed strong backgrounds in academic training. Members were trained and have served as professors at such respected institutions as Duke, Emory, Vanderbilt, MD Anderson and Memorial Sloan Kettering Cancer Center.

The background of basic science and clinical research in the early 1990's led to an affiliation with the National Cancer Institute to participate in community-based cancer trials. The fruition of this effort was the awarding of one of fifty Community Clinical Oncology Program (CCOP) grants to the practice in 1995.

With the extension of the practice to various sites around the Upstate and with the addition of capabilities to include Radiation Oncology, Diagnostic Radiology, Clinical Trials and Research and Autologous and Allogeneic Stem Cell Transplantation, the practice took on a new name: Cancer Centers of the Carolinas (CCC). This name is a better reflection of the true scope of our substantial capabilities. Through clinical excellence and research, CCC has been afforded the opportunity to care for thousands of patients in the Upstate of South Carolina and beyond.